Oncotarget: экспрессия PD-1 / PD-L1 в плоскоклеточных интраэпителиальных поражениях заднего прохода

Oncotarget недавно опубликовал « Экспрессию PD-1 / PD-L1 в плоскоклеточных интраэпителиальных поражениях заднего прохода », в котором сообщалось, что оценивали наличие и распределение лимфоцитов CD8, а также присутствие лимфоцитов PD-1 и эпителиальных клеток PD-L1. Лимфоциты CD8 чаще наблюдались в HSIL по сравнению с LSIL в собственной пластинке или внутриэпителиальном слое. Лимфоциты PD-1 наблюдались чаще при HSIL по сравнению с LSIL. Не было разницы между HSIL и LSIL для эпителиальных клеток PD-L1. Анальные диспластические поражения сопровождаются воспалительным лимфоцитарным инфильтратом, экспрессирующим CD8 и PD-1, что чаще встречается при поражениях высокой степени. Доктор Марго Букау из Hôpital Bichat-Claude Bernard сказала: « Анальная интраэпителиальная неоплазия (AIN) является предшественником плоскоклеточного рака заднего прохода (ASCC) ».

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