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Сообщения за январь, 2021

hospitals in us

Изображение
When people speak of contemporary medicine, accuracy plays one of the most crucial roles and human lives are directly dependent on it. Hereby, any researches related to medicine are required to meet the top standards. The problem nowadays is that any recommendations of researches can be published online and used as a reference without being adequately verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this problem and attempted to generate an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The major principle of this journal is based on Altmetric scores that are used as a quality indicator. That allows both readers and authors to quality-check publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a full publications list with respective scores higher than 100 as we

Metabolism of Breast Cancer Cells Exploited by Amino Acids

Researchers from Germany starved breast cancer cells of amino acids, including methionine, and exploited their dependency on the amino acid transporter SLC6A14. 3D Illustration of a chain of amino acids 3D Illustration of a chain of amino acids Cancerous tumors are greedy invaders. In order to sustain their signature high rate of growth, proliferation, and to increase their metabolic capacity, tumor cells demand more nutrients from the body, such as glucose and amino acids. One way that tumor cells elevate this intake of nutrients is by increasing the expression of genes that encode amino acid transporters. This knowledge provided new potential therapeutic targets for the authors of the cover paper for Oncotarget’s Vol 11, Issue #48. oncotarget impact factor “Targeting tumor metabolism has been explored as a strategy to inhibit tumor growth and proliferation due to the elevated metabolic requirements of cancer cells compared to their normal counterparts [1].” Researchers from Ger

us hospitals lists

Изображение
When people discuss modern medicine, precision plays one of the most crucial roles and human lives are literally dependent on it. Hereby, any researches related to medicine are required to meet the top standards. The challenge today is that any outcomes of researches can be posted online and used as a reference without being adequately verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and tried to develop an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality indicator. That assists both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website demonstrates a complete publications list with respective scores above 100 as well as reports mention

Trending with Impact: MSRE-PCR Detects Hypermethylated DNA in Tumors

Researchers identify genomic regions in DNA with hypermethylation, abundant MSRE sites, and low methylation levels that can be amplified and detected using MSRE-PCR analysis in diverse types of tumor DNA and normal tissue. Oncotarget oncotarget journal impact factor A pair of U.S. researchers from Johns Hopkins University in Baltimore, Maryland, and from Genmab—an international biotech company in Princeton, New Jersey—collaborated in a study to demonstrate: “Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR.” This study was published as the cover paper of journal Volume 11, Issue #47 in Oncotarget. Methylation Errors “Oncotarget” Methylation is an important process in multiple functions in human DNA, including gene regulation and silencing through the recruitment of proteins. After every cellular DNA replication cycle, DNA methyltransferase (DNMT) enzymes aid in performing on-the-spot DNA methylation to lock genes in the “off” position. DNMT enzy

hospitals in us

Изображение
When general population speak of today’s medicine, precision plays one of the most significant roles and people’s lives are directly dependent on it. Hence, any researches related to medicine are necessary to meet the top standards. The challenge today is that any recommendations of researches can be posted online and used as a reference without being thoroughly verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality measure. That allows both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website demonstrates a complete publications list with corresponding scores abov

us clinics lists

Изображение
When public speak of today’s medicine, accuracy plays one of the most significant roles and human lives are directly dependent on it. Hence, any researches related to medicine are required to meet the top standards. The challenge nowadays is that any results of researches can be shared online and used as a reference without being properly verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this problem and decided to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality indicator. That allows both readers and authors to quality-check publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a full publications list with respective scores higher than 100 as well as rep

Trending with Impact: Vitamin D Potential Use in BRCA1 Ovarian Cancer

In carriers of the BRCA1 gene mutation, researchers have found vitamin D biosynthesis and signaling to be impaired. This study provides a viable reason to explore the potential use of vitamin D in treatments to prevent ovarian cancer in women with the BRCA1 mutation. The Trending with Impact series highlights Oncotarget publications attracting higher visibility among readers around the world online, in the news, and on social media—beyond normal readership levels. Look for future science news and articles about the latest trending publications here, and at Oncotarget.com. Twitter Oncotarget Listen to an audio version of this article At this point in time, there is only one nutrient in the human body that can be generated via exposure to sunlight. Vitamin D is not only biologically produced by UV light; it can also be metabolized by eating oily fish, such as salmon and tuna, mushrooms, eggs, dairy products, and other vitamin D fortified foods and supplements. In additio

us clinics lists

Изображение
When people discuss modern medicine, accuracy plays one of the most important roles and human lives are directly dependent on it. Hereby, any researches pertaining to medicine are necessary to meet the top standards. The problem nowadays is that any results of researches can be published online and used as a reference without being thoroughly verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this problem and decided to create an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That helps both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website provides a full publications list with corresponding scores above 100 as well as reports di

Behind the Study: How ONC201 Kills Breast Cancer Cells

Scientists discuss their findings in a recently published paper in Oncotarget entitled, “ONC201 kills breast cancer cells in vitro by targeting mitochondria.” Oncotarget’s Behind The Study v1 The Behind the Study series transcribes videos of chosen researchers elaborating on their recent papers published in Oncotarget. Visit the Oncotarget YouTube channel for more insights from outstanding authors. Oncotarget Stan Lipkowitz Hello, I’m Stan Lipkowitz, the Branch Chief of the Women’s Malignancies Branch at the National Cancer Institute. Yoshimi Greer Hi, I’m Yoshimi Greer, Staff Scientist in Women’s Malignancies Branch, National Cancer Institute, NIH, Bethesda, Maryland. I’m the first author of the paper. Stan Lipkowitz So today we’d like to talk about our work with a novel class of drugs first described as a drug called ONC201 and a paper we published (in Oncotarget) on that demonstrating a novel mechanism of action, whereby the drugs target the mitochondria to kill bre

us clinics lists

Изображение
When public speak of contemporary medicine, precision plays one of the most important roles and human lives are directly dependent on it. Hence, any researches pertaining to medicine are necessary to comply with the top standards. The challenge nowadays is that any outcomes of researches can be posted online and used as a reference without being thoroughly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and decided to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The key principle of this journal is related to Altmetric scores that are used as a quality measure. That helps both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a complete publications list with respective scores higher than 100 as well as

hospitals in us

Изображение
When general population discuss modern medicine, precision plays one of the most important roles and human lives are literally dependent on it. Hence, any researches related to medicine are necessary to comply with the top standards. The problem nowadays is that any recommendations of researches can be published online and used as a reference without being thoroughly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and attempted to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That assists both readers and authors to verify publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a complete publications list with corresponding scores higher

Mikhail Blagosklonny of Oncotarget Proud to Support Ride for Roswell during Difficult Year

Now more than ever, the general public is witnessing the significance of medical research. The coronavirus pandemic has disrupted all our lives and will continue to do so until a vaccine is developed and distributed on a massive scale. This vaccine, once it finally arrives, will be the product of extensive development and testing. These efforts – whether it be for a virus vaccine or to combat cancer – cannot proceed without financial backing. Ride for Roswell acknowledges the importance of fiscal support. Rather than postpone its 2020 event, which is also its 25th consecutive year, organizers buckled down and found a work-around. “Summer of the Ride” is this year’s alternative and offers safe group rides as well as ride-from-home measures to encourage participation and donations. All told, Ride for Roswell has raised more than $55 million toward cancer research throughout its two-decade-plus run. Mikhail Blagosklonny, of peer-reviewed medical journal Oncotarget, is proud to be a part

us hospitals lists

Изображение
When people refer to contemporary medicine, precision plays one of the most important roles and human lives are directly dependent on it. Hence, any researches related to medicine are required to meet the highest standards. The problem today is that any results of researches can be published online and used as a reference without being thoroughly verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and tried to generate an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The main principle of this journal is based on Altmetric scores that are used as a quality measure. That allows both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website provides a complete publications list with corresponding scores above 100 as well as repor

Trending with Impact: Targets for Leukemia Learned From Down Syndrome

A recent study discovers new potential target mechanisms for leukemia treatments found in a novel study of down syndrome endothelial cells. Researcher at microscope The Trending with Impact series highlights publications attracting higher visibility among readers around the world online, in the news, and on social media beyond normal readership levels. Look for future science news and articles about the latest trending publications here. — Researchers from the Northwestern University Feinberg School of Medicine, Stanley Manne Children’s Research Institute, the Russian Academy of Sciences, and ARTEC Biotech Inc. were encouraged to learn more about the mechanisms involved in the increased risk of leukemia for people with down syndrome and how they also correlate with lower tumor expression. Previous studies have found that people with down syndrome present with a unique cancer profile. Their genetic material makes them vulnerable to certain cancers, such as leukemia, however, they al

hospitals in us

Изображение
When general population speak of today’s medicine, precision plays one of the most crucial roles and people’s lives are literally dependent on it. Likewise, any researches pertaining to medicine are required to comply with the top standards. The problem today is that any outcomes of researches can be published online and used as a reference without being thoroughly verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and decided to create an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality indicator. That helps both readers and authors to quality-check publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication. ” Oncotarget website demonstrates a full publications list with respective scores

clinics in us

Изображение
When general population discuss modern medicine, accuracy plays one of the most crucial roles and people’s lives are directly dependent on it. Likewise, any researches pertaining to medicine are required to meet the top standards. The challenge today is that any conclusions of researches can be shared online and used as a reference without being properly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality measure. That allows both readers and authors to validate publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a full publications list with corresponding scores higher than 100 a

Photodynamic Therapy Targets Nanoparticles in Breast Cancer

Researchers from South Africa compiled an overview of scientific papers related to studies using nanoparticles as photosensitizing drug transporters in targeted PDT treatment for breast cancer. Cancer cell in a crosshair - targeted tumor therapy Cancer cell in a crosshair – targeted tumor therapy The causes of breast cancer are primarily linked to mutations in DNA (found in genes including; HER2, p53, CHEK2, BRCA1, and BRCA2) and environmental factors. Given the vast number of people and families affected by this disease, scientists have developed an arsenal of conventional and unconventional treatment methods. Researchers from the University of Johannesburg’s Laser Research Centre in South Africa published a paper in Oncotarget about the use of a more unconventional treatment option, called targeted photodynamic therapy (PDT). The team reviewed a compilation of scientific studies published over a decade that relate to the treatment of breast cancer and functionalized organic nanopa

us clinics lists

Изображение
When public refer to contemporary medicine, precision plays one of the most significant roles and human lives are directly dependent on it. Hence, any researches related to medicine are necessary to meet the highest standards. The issue nowadays is that any outcomes of researches can be published online and used as a reference without being adequately checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and decided to create an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The main principle of this journal is based on Altmetric scores that are used as a quality indicator. That assists both readers and authors to verify publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a complete publications list with corresponding scores above 100 as well as rep

Trending with Impact: MSRE-PCR Detects Hypermethylated DNA in Tumors

Researchers identify genomic regions in DNA with hypermethylation, abundant MSRE sites, and low methylation levels that can be amplified and detected using MSRE-PCR analysis in diverse types of tumor DNA and normal tissue. DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity. DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity. A pair of U.S. researchers from Johns Hopkins University in Baltimore, Maryland, and from Genmab—an international biotech company in Princeton, New Jersey—collaborated in a study to demonstrate: “Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR.” This study was published as the cover paper of journal Volume 11, Issue #47 in Oncotarget. Methylation Errors Methylation is an important process in multiple functions in human DNA, including gene regulation and silencing through the rec

us clinics lists

Изображение
When general population mention contemporary medicine, precision plays one of the most important roles and human lives are literally dependent on it. Hence, any researches pertaining to medicine are required to comply with the highest standards. The problem nowadays is that any conclusions of researches can be posted online and used as a reference without being adequately checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and attempted to create an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That helps both readers and authors to quality-check publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a full publications list with respective scores higher th