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Metabolism of Breast Cancer Cells Exploited by Amino Acids

января 28, 2021

Researchers from Germany starved breast cancer cells of amino acids, including methionine, and exploited their dependency on the amino acid transporter SLC6A14. 3D Illustration of a chain of amino acids 3D Illustration of a chain of amino acids Cancerous tumors are greedy invaders. In order to sustain their signature high rate of growth, proliferation, and to increase their metabolic capacity, tumor cells demand more nutrients from the body, such as glucose and amino acids. One way that tumor cells elevate this intake of nutrients is by increasing the expression of genes that encode amino acid transporters. This knowledge provided new potential therapeutic targets for the authors of the cover paper for Oncotarget’s Vol 11, Issue #48. oncotarget impact factor “Targeting tumor metabolism has been explored as a strategy to inhibit tumor growth and proliferation due to the elevated metabolic requirements of cancer cells compared to their normal counterparts [1].” Researchers from Ger

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us hospitals lists

января 27, 2021

When people discuss modern medicine, precision plays one of the most crucial roles and human lives are literally dependent on it. Hereby, any researches related to medicine are required to meet the top standards. The challenge today is that any outcomes of researches can be posted online and used as a reference without being adequately verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and tried to develop an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality indicator. That assists both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website demonstrates a complete publications list with respective scores above 100 as well as reports mention

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Trending with Impact: MSRE-PCR Detects Hypermethylated DNA in Tumors

января 26, 2021

Researchers identify genomic regions in DNA with hypermethylation, abundant MSRE sites, and low methylation levels that can be amplified and detected using MSRE-PCR analysis in diverse types of tumor DNA and normal tissue. Oncotarget oncotarget journal impact factor A pair of U.S. researchers from Johns Hopkins University in Baltimore, Maryland, and from Genmab—an international biotech company in Princeton, New Jersey—collaborated in a study to demonstrate: “Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR.” This study was published as the cover paper of journal Volume 11, Issue #47 in Oncotarget. Methylation Errors “Oncotarget” Methylation is an important process in multiple functions in human DNA, including gene regulation and silencing through the recruitment of proteins. After every cellular DNA replication cycle, DNA methyltransferase (DNMT) enzymes aid in performing on-the-spot DNA methylation to lock genes in the “off” position. DNMT enzy

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hospitals in us

января 26, 2021

When general population speak of today’s medicine, precision plays one of the most significant roles and people’s lives are directly dependent on it. Hence, any researches related to medicine are necessary to meet the top standards. The challenge today is that any recommendations of researches can be posted online and used as a reference without being thoroughly verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality measure. That allows both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website demonstrates a complete publications list with corresponding scores abov

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us clinics lists

января 21, 2021

When public speak of today’s medicine, accuracy plays one of the most significant roles and human lives are directly dependent on it. Hence, any researches related to medicine are required to meet the top standards. The challenge nowadays is that any results of researches can be shared online and used as a reference without being properly verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this problem and decided to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality indicator. That allows both readers and authors to quality-check publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a full publications list with respective scores higher than 100 as well as rep

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Trending with Impact: Vitamin D Potential Use in BRCA1 Ovarian Cancer

января 21, 2021

In carriers of the BRCA1 gene mutation, researchers have found vitamin D biosynthesis and signaling to be impaired. This study provides a viable reason to explore the potential use of vitamin D in treatments to prevent ovarian cancer in women with the BRCA1 mutation. The Trending with Impact series highlights Oncotarget publications attracting higher visibility among readers around the world online, in the news, and on social media—beyond normal readership levels. Look for future science news and articles about the latest trending publications here, and at Oncotarget.com. Twitter Oncotarget Listen to an audio version of this article At this point in time, there is only one nutrient in the human body that can be generated via exposure to sunlight. Vitamin D is not only biologically produced by UV light; it can also be metabolized by eating oily fish, such as salmon and tuna, mushrooms, eggs, dairy products, and other vitamin D fortified foods and supplements. In additio

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